Archive: Jan 2019

  1. The Truth… are we all being poisoned by agents that reduce Testosterone?

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    The term Endocrine Disrupters (EDC) was first coined in 1991 at the Wingspread Conference Centre in Racine, Wisconsin. At this meeting researchers from several different disciplines came to the consensus that “a large number of man-made chemicals” have been released into the environment with the potential to “disrupt” the Endocrine system of humans.

    Recently, there has been a surge of research investigating the role of EDC’s in human health and the Endocrine Society stated in 2015 that this expansion of data “removes any doubt that EDC’s are contributing to increased chronic disease burdens”

    Studies have demonstrated that EDC’s can act at multiple sites in the hormone pathway including binding to the hormone receptor and acting on proteins that regulate hormone synthesis, metabolism and delivery.

    Plastics and Plasticisers

    BPA (Bisphenol A) is one of the highest volume chemicals produced world wide and present in many plastics used for food and drink storage.  One study Li et al demonstrated association between urinary levels of BPA and sexual function in 427 male workers. They found that increasing urine BPA level was associated with decreased sexual desire, more difficulty having an erection, lower ejaculation strength and lower level of overall satisfaction with sex life.

    Phthalate is predominantly used as a plasticiser (a substance added to plastics to modify its properties i.e increase flexibility). It is in many items in common use. There have been many studies looking at the hazards of this chemical with conflicting results.

    PCB’s (Polychlorinated biphenyls) In the last decade there have been several human studies evaluating the impact of PCB exposure to semen quality, again with conflicting results.

    Conclusion: Currently there is a wealth of animal studies linking sexual dysfunction and reproductive abnormalities to endocrine disrupters, however, more research is needed in humans especially with a focus on the impact of different timed exposures.

    (This information was discussed in the December issue of ESSM newsletter.)

    Dr Savage feels that having worked in this field for the last 30 years at The Leger Clinic Ltd., he has been alarmed at the number of apparently “healthy” young men who present with classic symptoms of Testosterone Deficiency and lowish levels of Testosterone. No-one seems to have a good explanation of why these people have this problem.

    Dr. Savage frequently raises his concerns with some of the worlds top andrologists who he meets at international meetings he attends.

    To make an appointment to discuss your concerns about your Testosterone levels please make an appointment at The Leger Clinic Ltd

    Dr. Savage will be attending the European Society of Sexual Medicine, 3 day annual meeting in Ljubljana in Slovenia this February and will be reporting back on the latest research, thinking and developments in the field of Sexual Medicine.







  2. Testosterone as effective as antidepressants for men?

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    An article in The Times  last year stated, “Testosterone is as effective as the use of antidepressants for men with depression, according to an overview of research. Doctors should consider Testosterone as an alternative to medicines that are under increasing scrutiny about overuse and the effects of withdrawal scientist suggested. Psychiatrists said that the results showed that testosterone was likely to have a role in treating depression but that further studies were needed. It was twice as effective as a placebo, a level comparable to antidepressants, a team from Technische Universitadt Dresden said in the JAMA Psychiatry.

    Dr. Savage has seen many patients over the years who have been diagnosed as suffering from depression by their GP and given antidepressants, indeed often several sorts of antidepressants with no benefit to the patient. Some of the patients have raised with their GP following their own research on the internet, “could this be testosterone deficiency?” but this suggestion has mainly been dismissed and indeed, sadly most GP’s have refused to do the appropriate blood tests.

    As you are probably aware, there is great concern about the mental health of young people and indeed, even the worrying suicide rate in young men, one wonders is there  a correlation?

    A patient has even said to me “If you were told that the diagnosis is depression, you have failed to respond to either antidepressants or talking therapies, you would feel desperate, wouldn’t you”.

    At the other end of the age scale, I can always remember seeing a man in his 70’s who had been diagnosed with severe depression by his GP, unresponsive to treatment who had been therefore referred to a Psychiatrist, however, this too made no difference. His wife in particular was severely distressed about her husbands state but told me that what was one of the most distressing things about her husbands symptoms was drenching night sweats to the degree that neither of them could sleep. This was to me a classic symptom of testosterone deficiency and indeed I did the appropriate blood tests to test for low testosterone and we all waited with baited breath to see if in fact this was the diagnosis. IT WAS! He had a fantastic response to testosterone treatment, they told me it had changed both their lives and indeed had given them back their quality of life in retirement.


    To see if this could be your story, book an appointment to see Dr. Savage